SAR407899 [Ligand Id: 8910] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1667969 (SAR-407899)
  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2 in Human [GtoPdb: 1504] [UniProtKB: O75116]
  • Rho associated coiled-coil containing protein kinase 2 in Rat [GtoPdb: 1504] [UniProtKB: Q62868]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb - - 6.56 pIC50 276 nM IC50 Hypertension (2009) 54: 676-83 [PMID:19597037]
ChEMBL Inhibition of ROCK1 by IMAP assay B 6.73 pIC50 186.21 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1084-1088 [PMID:21251828]
Rho associated coiled-coil containing protein kinase 2 in Human [GtoPdb: 1504] [UniProtKB: O75116]
GtoPdb - - 7.44 pKi 36 nM Ki Hypertension (2009) 54: 676-83 [PMID:19597037]
GtoPdb - - 6.99 pIC50 102 nM IC50 Hypertension (2009) 54: 676-83 [PMID:19597037]
Rho associated coiled-coil containing protein kinase 2 in Rat [GtoPdb: 1504] [UniProtKB: Q62868]
GtoPdb - - 7.39 pKi 41 nM Ki Hypertension (2009) 54: 676-83 [PMID:19597037]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]