acalabrutinib [Ligand Id: 8912] activity data from GtoPdb

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  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
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  • erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303]
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  • BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
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  • BMX non-receptor tyrosine kinase in Human [GtoPdb: 1942] [UniProtKB: P51813]
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  • Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187]
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  • erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
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  • FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241]
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  • IL2 inducible T cell kinase in Human [GtoPdb: 2046] [UniProtKB: Q08881]
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  • Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
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  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
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  • LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
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  • SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
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  • tec protein tyrosine kinase in Human [GtoPdb: 2238] [UniProtKB: P42680]
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  • TXK tyrosine kinase in Human [GtoPdb: 2268] [UniProtKB: P42681]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303]
GtoPdb - - 7.8 pIC50 16 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
BMX non-receptor tyrosine kinase in Human [GtoPdb: 1942] [UniProtKB: P51813]
GtoPdb - - 7.34 pIC50 46 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187]
GtoPdb - - 8.29 pIC50 5.1 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
GtoPdb - - 8 pEC50 <10 nM EC50 US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241]
GtoPdb - - 6 pEC50 >1000 nM EC50 US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
IL2 inducible T cell kinase in Human [GtoPdb: 2046] [UniProtKB: Q08881]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 6 pEC50 >1000 nM EC50 US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb - - 6 pIC50 >1000 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
GtoPdb - - 6 pEC50 1000 nM EC50 US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb - - 6 pEC50 >1000 nM EC50 US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
tec protein tyrosine kinase in Human [GtoPdb: 2238] [UniProtKB: P42680]
GtoPdb - - 7.03 pIC50 93 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]
TXK tyrosine kinase in Human [GtoPdb: 2268] [UniProtKB: P42681]
GtoPdb - - 6.43 pIC50 368 nM IC50 N. Engl. J. Med. (2016) 374: 323-32 [PMID:26641137]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.