ADL5747 [Ligand Id: 9003] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL561339
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cells B 8.57 pKi 2.7 nM Ki J Med Chem (2009) 52: 5685-5702 [PMID:19694468]
GtoPdb - - 8.57 pKi 2.7 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]
ChEMBL Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding F 7.03 pEC50 94 nM EC50 J Med Chem (2009) 52: 5685-5702 [PMID:19694468]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay B 4.25 pIC50 56700 nM IC50 J Med Chem (2009) 52: 5685-5702 [PMID:19694468]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 7.6 pKi 25 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 7.74 pKi 18 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]