ADL5747 [Ligand Id: 9003] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL561339
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cells B 8.57 pKi 2.7 nM Ki J. Med. Chem. (2009) 52: 5685-5702 [PMID:19694468]
GtoPdb - - 8.57 pKi 2.7 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]
ChEMBL Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding F 7.03 pEC50 94 nM EC50 J. Med. Chem. (2009) 52: 5685-5702 [PMID:19694468]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay B 4.25 pIC50 56700 nM IC50 J. Med. Chem. (2009) 52: 5685-5702 [PMID:19694468]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 7.6 pKi 25 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 7.74 pKi 18 nM Ki J Med Chem (2009) 52: 5685-702 [PMID:19694468]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]