852A [Ligand Id: 9025] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL549344 (Cpg-52852, PF-4878691)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1]
ChEMBL Agonist activity at human TLR7 expressed in HEK293 cells by NFkappaB SEAP reporter gene assay B 5.58 pEC50 2657 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 669-672 [PMID:23265901]
GtoPdb - - 5.58 pEC50 2657 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-72 [PMID:23265901]
TLR7/Toll-like receptor 7 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6085] [GtoPdb: 1757] [UniProtKB: P58681]
ChEMBL Agonist activity at mouse TLR7 B 5.21 pEC50 6224 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 669-672 [PMID:23265901]
GtoPdb - - 5.21 pEC50 6224 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-72 [PMID:23265901]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]