852A [Ligand Id: 9025] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL549344 (Cpg-52852, PF-4878691)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1]
ChEMBL Agonist activity at human TLR7 expressed in HEK293 cells by NFkappaB SEAP reporter gene assay B 5.58 pEC50 2657 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-672 [PMID:23265901]
GtoPdb - - 5.58 pEC50 2657 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-72 [PMID:23265901]
TLR7/Toll-like receptor 7 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6085] [GtoPdb: 1757] [UniProtKB: P58681]
ChEMBL Agonist activity at mouse TLR7 B 5.21 pEC50 6224 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-672 [PMID:23265901]
GtoPdb - - 5.21 pEC50 6224 nM EC50 Bioorg Med Chem Lett (2013) 23: 669-72 [PMID:23265901]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]