motolimod [Ligand Id: 9026] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3301618 (Motolimod, VTX-2337, VTX-378) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1] | ||||||||
| ChEMBL | Agonist activity at TLR7 in human cryopreserved PBMC assessed as induction of IFNalpha production measured after 24 hrs | B | 4.52 | pEC50 | >30000 | nM | EC50 | J Med Chem (2020) 63: 10188-10203 [PMID:32407112] |
| TLR8/Toll-like receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5805] [GtoPdb: 1758] [UniProtKB: Q9NR97] | ||||||||
| ChEMBL | Agonist activity at TLR8 in human cryopreserved PBMC assessed as inhibition of IL-12p40 production measured after 24 hrs | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2020) 63: 10188-10203 [PMID:32407112] |
| GtoPdb | - | - | 7 | pEC50 | ~100 | nM | EC50 | Clin Cancer Res (2012) 18: 499-509 [PMID:22128302] |
| ChEMBL | Agonist activity at TLR8 (unknown origin) | B | 7 | pEC50 | 100 | nM | EC50 | Eur J Med Chem (2020) 193: 112238-112238 [PMID:32203790] |
| ChEMBL | Agonist activity at TLR8 (unknown origin) | B | 7 | pEC50 | 100 | nM | EC50 | RSC Med Chem (2021) 12: 1065-1120 [PMID:34355178] |
| ChEMBL | Agonist activity at human TLR8 expressed in HEK293 cells by reporter gene assay | B | 7 | pEC50 | 100 | nM | EC50 | Eur J Med Chem (2018) 157: 582-598 [PMID:30125720] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
