PD-135666 [Ligand Id: 903] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL138534 (PD-135666)
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
There should be some charts here, you may need to enable JavaScript!
  • CCK2 receptor/Cholecystokinin B receptor in Mouse [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
ChEMBL Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-A receptor in the rat pancreas. B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (1993) 3: 989-992
ChEMBL Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas B 7.59 pIC50 25.5 nM IC50 J Med Chem (1998) 41: 38-45 [PMID:9438020]
ChEMBL Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas B 7.59 pIC50 25.5 nM IC50 J Med Chem (2000) 43: 3505-3517 [PMID:11000005]
ChEMBL Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas B 7.59 pIC50 25.5 nM IC50 Bioorg Med Chem Lett (1993) 3: 881-884
CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481]
ChEMBL Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse B 9.83 pKi 0.15 nM Ki J Med Chem (1992) 35: 1572-1577 [PMID:1578483]
GtoPdb - - 9.8 pIC50 - - - Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955]
ChEMBL Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex B 9.82 pIC50 0.15 nM IC50 J Med Chem (1998) 41: 38-45 [PMID:9438020]
ChEMBL Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex B 9.82 pIC50 0.15 nM IC50 J Med Chem (2000) 43: 3505-3517 [PMID:11000005]
ChEMBL Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex. B 9.82 pIC50 0.15 nM IC50 Bioorg Med Chem Lett (1993) 3: 989-992
ChEMBL Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. B 9.82 pIC50 0.15 nM IC50 Bioorg Med Chem Lett (1993) 3: 881-884

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]