PD-135666 [Ligand Id: 903] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL138534 (PD-135666) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-A receptor in the rat pancreas. | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 989-992 |
| ChEMBL | Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | J Med Chem (1998) 41: 38-45 [PMID:9438020] |
| ChEMBL | Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse | B | 9.83 | pKi | 0.15 | nM | Ki | J Med Chem (1992) 35: 1572-1577 [PMID:1578483] |
| GtoPdb | - | - | 9.8 | pIC50 | - | - | - | Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955] |
| ChEMBL | Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (1998) 41: 38-45 [PMID:9438020] |
| ChEMBL | Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 989-992 |
| ChEMBL | Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
