PD-135666 [Ligand Id: 903] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL138534 (PD-135666) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-A receptor in the rat pancreas. | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 989-992 |
| ChEMBL | Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | J Med Chem (1998) 41: 38-45 [PMID:9438020] |
| ChEMBL | Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor of rat pancreas | B | 7.59 | pIC50 | 25.5 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse | B | 9.83 | pKi | 0.15 | nM | Ki | J Med Chem (1992) 35: 1572-1577 [PMID:1578483] |
| GtoPdb | - | - | 9.8 | pIC50 | - | - | - | Eur J Pharmacol (1995) 286: 185-91 [PMID:8605955] |
| ChEMBL | Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (1998) 41: 38-45 [PMID:9438020] |
| ChEMBL | Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 989-992 |
| ChEMBL | Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex. | B | 9.82 | pIC50 | 0.15 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 881-884 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
