PF-03882845 [Ligand Id: 9061] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1215331 (PF-3882845) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| GtoPdb | - | - | 5.05 | pIC50 | 8910 | nM | IC50 | J Med Chem (2014) 57: 4273-88 [PMID:24738581] |
| ChEMBL | Antagonist activity at androgen receptor | F | 5.05 | pIC50 | >8910 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at androgen receptor (unknown origin) by Gal4-based cellular assay | B | 5.05 | pIC50 | >8910 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Antagonist activity at estrogen receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Antagonist activity at glucocorticoid receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at glucocorticoid receptor (unknown origin) by Gal4-based cellular assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] | ||||||||
| ChEMBL | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay | F | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assay | B | 8.04 | pIC50 | 9.2 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| GtoPdb | - | - | 8.04 | pIC50 | 9.2 | nM | IC50 | J Med Chem (2014) 57: 4273-88 [PMID:24738581] |
| ChEMBL | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Binding affinity to mineralocorticoid receptor (unknown origin) | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| GtoPdb | - | - | 6.38 | pIC50 | 416 | nM | IC50 | J Med Chem (2014) 57: 4273-88 [PMID:24738581] |
| ChEMBL | Antagonist activity at progesterone receptor | F | 6.38 | pIC50 | 416 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at progesterone receptor (unknown origin) by Gal4-based cellular assay | B | 6.38 | pIC50 | 416 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
