PF-03882845 [Ligand Id: 9061] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1215331 (PF-3882845)
  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1215331_lig_chart_1 Androgen Receptor Human
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  • Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1215331_lig_chart_2 Estrogen receptor alpha Human
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  • Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1215331_lig_chart_3 Glucocorticoid receptor Human
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  • Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
  • This target only has 0 pki data point
  • 0
4 CHEMBL1215331_lig_chart_4 Mineralocorticoid receptor Human
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  • Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
  • This target only has 0 pki data point
  • 0
5 CHEMBL1215331_lig_chart_5 Progesterone receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
GtoPdb - - 5.05 pIC50 8910 nM IC50 J Med Chem (2014) 57: 4273-88 [PMID:24738581]
ChEMBL Antagonist activity at androgen receptor F 5.05 pIC50 >8910 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
ChEMBL Antagonist activity at androgen receptor (unknown origin) by Gal4-based cellular assay B 5.05 pIC50 >8910 nM IC50 J. Med. Chem. (2014) 57: 4273-4288 [PMID:24738581]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL Antagonist activity at estrogen receptor F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL Antagonist activity at glucocorticoid receptor F 5 pIC50 >10000 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
ChEMBL Antagonist activity at glucocorticoid receptor (unknown origin) by Gal4-based cellular assay B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2014) 57: 4273-4288 [PMID:24738581]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay F 7.68 pIC50 21 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
ChEMBL Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assay B 8.04 pIC50 9.2 nM IC50 J. Med. Chem. (2014) 57: 4273-4288 [PMID:24738581]
GtoPdb - - 8.04 pIC50 9.2 nM IC50 J Med Chem (2014) 57: 4273-88 [PMID:24738581]
ChEMBL Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay F 8.05 pIC50 9 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
ChEMBL Binding affinity to mineralocorticoid receptor (unknown origin) B 8.05 pIC50 9 nM IC50 J. Med. Chem. (2014) 57: 4273-4288 [PMID:24738581]
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
GtoPdb - - 6.38 pIC50 416 nM IC50 J Med Chem (2014) 57: 4273-88 [PMID:24738581]
ChEMBL Antagonist activity at progesterone receptor F 6.38 pIC50 416 nM IC50 J. Med. Chem. (2010) 53: 5979-6002 [PMID:20672822]
ChEMBL Antagonist activity at progesterone receptor (unknown origin) by Gal4-based cellular assay B 6.38 pIC50 416 nM IC50 J. Med. Chem. (2014) 57: 4273-4288 [PMID:24738581]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]