SC-22716 [Ligand Id: 9102] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL119054 (SC-22716) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
| ChEMBL | Inhibitory activity was determined for LTB4 production in human whole blood. | F | 6.1 | pIC50 | 790 | nM | IC50 | J Med Chem (2000) 43: 721-735 [PMID:10691697] |
| ChEMBL | Inhibition of human whole blood LTB-4 production (Leukotriene B-4). | F | 6.1 | pIC50 | 790 | nM | IC50 | J Med Chem (2002) 45: 3482-3490 [PMID:12139459] |
| ChEMBL | Inhibitory activity was determined against Leukotriene A4 hydrolase | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2000) 43: 721-735 [PMID:10691697] |
| ChEMBL | Inhibition of human leukotriene A4 hydrolase (LTA-4). | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2002) 45: 3482-3490 [PMID:12139459] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2000) 43: 721-35 [PMID:10691697] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
