SC-22716 [Ligand Id: 9102] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL119054 (SC-22716)
  • Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL Inhibitory activity was determined for LTB4 production in human whole blood. F 6.1 pIC50 790 nM IC50 J. Med. Chem. (2000) 43: 721-735 [PMID:10691697]
ChEMBL Inhibition of human whole blood LTB-4 production (Leukotriene B-4). F 6.1 pIC50 790 nM IC50 J. Med. Chem. (2002) 45: 3482-3490 [PMID:12139459]
ChEMBL Inhibitory activity was determined against Leukotriene A4 hydrolase B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2000) 43: 721-735 [PMID:10691697]
ChEMBL Inhibition of human leukotriene A4 hydrolase (LTA-4). B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2002) 45: 3482-3490 [PMID:12139459]
GtoPdb - - 6.7 pIC50 200 nM IC50 J Med Chem (2000) 43: 721-35 [PMID:10691697]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]