naldemedine [Ligand Id: 9150] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2105755
  • δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 9.04 pKi 0.91 nM Ki Bioorg. Med. Chem. Lett. (2019) 29: 73-77 [PMID:30446313]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 8.95 pKi 1.13 nM Ki Bioorg. Med. Chem. Lett. (2019) 29: 73-77 [PMID:30446313]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]