C108297 [Ligand Id: 9180] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL270575
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
GtoPdb - - 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 1312-7 [PMID:18226897]
ChEMBL Displacement of [3H]dexamethasone from human recombinant GR B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 1312-1317 [PMID:18226897]
ChEMBL Antagonist activity at GR in SW1353/MMTV5 cells assessed as inhibition of dexamethasone-induced luciferase expression F 9.22 pKi 0.6 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 1312-1317 [PMID:18226897]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]