periciazine [Ligand Id: 9216] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL251940 (Neulactil, NSC-758641, Periciazine, Pericyazine, Propericiazine, RP 8909, RP-8909, SKF 20716, SKF-20716)
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  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
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  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assay B 5.15 pIC50 7000 nM IC50 Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL Displacement of [3H]mibolerone from rat androgen receptor B 5.52 pKi 3000 nM Ki Proc Natl Acad Sci U S A (2007) 104: 11927-11932 [PMID:17606915]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assay B 6.64 pIC50 230 nM IC50 Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay F 5.18 pIC50 6562 nM IC50 Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 8 pKi 10 nM Ki J Psychiatry Neurosci (1994) 19: 265-9 [PMID:7918347]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]