compound 4g [PMID: 22220592] [Ligand Id: 9236] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2024115
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting B 7.07 pKi 85.11 nM Ki J. Med. Chem. (2012) 55: 1898-1903 [PMID:22220592]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity to adenosine A2A receptor by surface plasmon resonance B 8.9 pKd 1.26 nM Kd J. Med. Chem. (2012) 55: 1898-1903 [PMID:22220592]
GtoPdb - - 8.11 pKi 7.76 nM Ki J Med Chem (2012) 55: 1898-903 [PMID:22220592]
ChEMBL Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting B 8.11 pKi 7.76 nM Ki J. Med. Chem. (2012) 55: 1898-1903 [PMID:22220592]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL Inhibition of adenosine A2B receptor B 7.3 pKi 50.12 nM Ki J. Med. Chem. (2012) 55: 1898-1903 [PMID:22220592]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]