compound 27f [PMID: 25625617] [Ligand Id: 9238] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3410084
  • TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
GtoPdb Biochemical assay - 8.55 pIC50 2.8 nM IC50 J Med Chem (2015) 58: 1760-75 [PMID:25625617]
ChEMBL Inhibition of Mps1 (unknown origin)-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assay B 8.55 pIC50 2.8 nM IC50 J Med Chem (2015) 58: 1760-1775 [PMID:25625617]
ChEMBL Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRET assay B 8.55 pIC50 2.8 nM IC50 Eur J Med Chem (2019) 175: 247-268 [PMID:31121430]
ChEMBL Inhibition of FLAG-tagged Mps1 autophosphorylation in human RERF-LC-AI cells expressing Tet-suppressible promotor after 3 hrs by immunoblotting B 9.15 pIC50 0.7 nM IC50 J Med Chem (2015) 58: 1760-1775 [PMID:25625617]
ChEMBL Inhibition of MPS1 (unknown origin) by cell based assay B 9.15 pIC50 0.7 nM IC50 Eur J Med Chem (2019) 175: 247-268 [PMID:31121430]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]