compound 27f [PMID: 25625617] [Ligand Id: 9238] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3410084 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
| GtoPdb | Biochemical assay | - | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2015) 58: 1760-75 [PMID:25625617] |
| ChEMBL | Inhibition of Mps1 (unknown origin)-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assay | B | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2015) 58: 1760-1775 [PMID:25625617] |
| ChEMBL | Inhibition of MPS1 (unknown origin) using biotin-AhxPWDPDDADITEILG-NH2 as substrate preincubated for 15 mins followed by substrate addition by TR-FRET assay | B | 8.55 | pIC50 | 2.8 | nM | IC50 | Eur J Med Chem (2019) 175: 247-268 [PMID:31121430] |
| ChEMBL | Inhibition of FLAG-tagged Mps1 autophosphorylation in human RERF-LC-AI cells expressing Tet-suppressible promotor after 3 hrs by immunoblotting | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2015) 58: 1760-1775 [PMID:25625617] |
| ChEMBL | Inhibition of MPS1 (unknown origin) by cell based assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Eur J Med Chem (2019) 175: 247-268 [PMID:31121430] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
