setmelanotide [Ligand Id: 9272] activity data from GtoPdb

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  • MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
  • This target only has 1 pki data point
  • 8.41
1 _lig_chart_1 MC1 receptor Human
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  • MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
  • This target only has 1 pki data point
  • 8
2 _lig_chart_2 MC3 receptor Human
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  • MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
  • MC4 receptor in Rat [GtoPdb: 285] [UniProtKB: P70596]
  • 8.57
3 _lig_chart_3 MC4 receptor HumanRat
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  • MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
  • This target only has 1 pki data point
  • 6.37
4 _lig_chart_4 MC5 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726]
GtoPdb - - 8.41 pKi 3.9 nM Ki Peptides (2009) 30: 1892-900 [PMID:19646498]
MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968]
GtoPdb - - 8 pKi 10 nM Ki Peptides (2009) 30: 1892-900 [PMID:19646498]
MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245]
GtoPdb - - 8.68 pKi 2.1 nM Ki Peptides (2009) 30: 1892-900 [PMID:19646498];
Lancet Diabetes Endocrinol (2020) 8: 960-970 [PMID:33137293]
MC4 receptor in Rat [GtoPdb: 285] [UniProtKB: P70596]
GtoPdb - - 8.57 pKi 2.7 nM Ki Peptides (2009) 30: 1892-900 [PMID:19646498]
MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032]
GtoPdb - - 6.37 pKi 430 nM Ki Peptides (2009) 30: 1892-900 [PMID:19646498]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.