RWJ-56423 [Ligand Id: 9333] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL256892 (RWJ-56423)
  • serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
  • serine protease 1 in Bovine [GtoPdb: 2397]
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  • tryptase alpha/beta 1 in Human [GtoPdb: 2424] [UniProtKB: Q15661]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
ChEMBL Binding affinity against human alpha trypsin B 8.09 pKi 8.1 nM Ki J. Med. Chem. (2004) 47: 769-787 [PMID:14761180]
serine protease 1 in Bovine [GtoPdb: 2397]
GtoPdb - - 8.09 pKi 8.09 nM Ki J. Med. Chem. (2003) 46: 3865-76 [PMID:12930148]
tryptase alpha/beta 1 in Human [GtoPdb: 2424] [UniProtKB: Q15661]
GtoPdb - - 8 pKi 10 nM Ki J. Med. Chem. (2003) 46: 3865-76 [PMID:12930148]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]