DDR-IN-1 [Ligand Id: 9354] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3421914
  • discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
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  • discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
ChEMBL Inhibition of human DDR1 kinase domain (601 to 913 residues) expressed in Sf9 cells by enzymatic kinase assay B 6.98 pIC50 105 nM IC50 J. Med. Chem. (2015) 58: 3287-3301 [PMID:25569119]
GtoPdb In a Lanthascreen enzyme assay - 6.98 pIC50 105 nM IC50 ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692]
ChEMBL Inhibition of human DDR1 in doxycycline-stimulated human U2OS cells assessed as inhibition of collagen-1-induced autophosphorylation incubated for 1 hr B 7.07 pIC50 86 nM IC50 J. Med. Chem. (2015) 58: 3287-3301 [PMID:25569119]
discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
GtoPdb In a Lanthascreen enzyme assay - 6.38 pIC50 413 nM IC50 ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]