DDR-IN-1 [Ligand Id: 9354] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL3421914
  • discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
There should be some charts here, you may need to enable JavaScript!
  • discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
ChEMBL Inhibition of human DDR1 kinase domain (601 to 913 residues) expressed in Sf9 cells by enzymatic kinase assay B 6.98 pIC50 105 nM IC50 J Med Chem (2015) 58: 3287-3301 [PMID:25569119]
GtoPdb In a Lanthascreen enzyme assay - 6.98 pIC50 105 nM IC50 ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692]
ChEMBL Inhibition of human DDR1 in doxycycline-stimulated human U2OS cells assessed as inhibition of collagen-1-induced autophosphorylation incubated for 1 hr B 7.07 pIC50 86 nM IC50 J Med Chem (2015) 58: 3287-3301 [PMID:25569119]
discoidin domain receptor tyrosine kinase 2 in Human [GtoPdb: 1844] [UniProtKB: Q16832]
GtoPdb In a Lanthascreen enzyme assay - 6.38 pIC50 413 nM IC50 ACS Chem Biol (2013) 8: 2145-50 [PMID:23899692]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]