MELK-TI [Ligand Id: 9366] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3355059
  • maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • calcium/calmodulin-dependent protein kinase II delta subunit in Human [GtoPdb: 1558] [UniProtKB: Q13557]
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  • MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
ChEMBL Inhibition of MELK kinase (unknown origin) using KKLNRTLSFAEPG/gamma[33P]ATP by Millipore kinase/scintillation counting analysis B 4.64 pIC50 23000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 25-30 [PMID:25589925]
ChEMBL Inhibition of MELK kinase (unknown origin) using biotinylated ZIP-tide peptide/gamma[33P]ATP by scintillation counting analysis B 7.43 pIC50 37 nM IC50 ACS Med. Chem. Lett. (2015) 6: 25-30 [PMID:25589925]
ChEMBL Inhibition of MELK (unknown origin) B 7.43 pIC50 37 nM IC50 ACS Med. Chem. Lett. (2015) 6: 31-36 [PMID:25589926]
GtoPdb Measured in a MIllipore kinase screening assay - 7.64 pIC50 23 nM IC50 ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Inhibition of Flt3 (unknown origin) by Millipore kinase analysis B 4.74 pIC50 18000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 25-30 [PMID:25589925]
GtoPdb Measured in a MIllipore kinase screening panel assay - 7.74 pIC50 18 nM IC50 ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925]
calcium/calmodulin-dependent protein kinase II delta subunit in Human [GtoPdb: 1558] [UniProtKB: Q13557]
GtoPdb Measured in a MIllipore kinase screening panel assay - 6.09 pIC50 810 nM IC50 ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925]
MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9]
GtoPdb Measured in a MIllipore kinase screening assay - 6.12 pIC50 760 nM IC50 ACS Med Chem Lett (2014) 6: 25-30 [PMID:25589925]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]