esflurbiprofen [Ligand Id: 9420] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL435298 (BTS 24332, BTS-24332, Esflurbiprofen, Flurbiprofen, (s)-)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 in human whole blood F 5.7 pIC50 2000 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2219-2223 [PMID:16455248]
COX-1 /Cyclooxygenase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4042] [GtoPdb: 1375] [UniProtKB: Q63921]
ChEMBL Concentration required to inhibit cyclooxygenase-1 in rat blood B 7.52 pIC50 30 nM IC50 J. Med. Chem. (2005) 48: 5705-5720 [PMID:16134939]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb Inhibition of COX-2 in human blood. - 6.04 pIC50 910 nM IC50 J Clin Pharmacol (1996) 36: 513-20 [PMID:8809636]
ChEMBL Concentration required to inhibit cyclooxygenase-2 in human blood B 6.04 pIC50 910 nM IC50 J. Med. Chem. (2005) 48: 5705-5720 [PMID:16134939]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]