esflurbiprofen [Ligand Id: 9420] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL435298 (BTS 24332, BTS-24332, Esflurbiprofen, Flurbiprofen, (s)-) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 in human whole blood | F | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2219-2223 [PMID:16455248] |
| COX-1 /Cyclooxygenase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4042] [GtoPdb: 1375] [UniProtKB: Q63921] | ||||||||
| ChEMBL | Concentration required to inhibit cyclooxygenase-1 in rat blood | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2005) 48: 5705-5720 [PMID:16134939] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| GtoPdb | Inhibition of COX-2 in human blood. | - | 6.04 | pIC50 | 910 | nM | IC50 | J Clin Pharmacol (1996) 36: 513-20 [PMID:8809636] |
| ChEMBL | Concentration required to inhibit cyclooxygenase-2 in human blood | B | 6.04 | pIC50 | 910 | nM | IC50 | J Med Chem (2005) 48: 5705-5720 [PMID:16134939] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
