CYM-5541 [Ligand Id: 9494] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1970071 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
| ChEMBL | Agonist activity at S1P1 receptor (unknown origin) | B | 4.48 | pEC50 | 33300 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6346-6349 [PMID:24135724] |
| S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500] | ||||||||
| ChEMBL | Agonist activity at human S1P3 receptor expressed in CHO cells after 4 hrs by fluorescence assay | B | 6.98 | pEC50 | 105 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6346-6349 [PMID:24135724] |
| GtoPdb | In a β-arrestin assay. | - | 8.5 | pA2 | - | - | - | Mol Pharmacol (2016) 89: 176-86 [PMID:26494861] |
| S1P2 receptor/Sphingosine 1-phosphate receptor Edg-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2955] [GtoPdb: 276] [UniProtKB: O95136] | ||||||||
| ChEMBL | Agonist activity at S1P2 receptor (unknown origin) | B | 4.3 | pEC50 | >50000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6346-6349 [PMID:24135724] |
| S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977] | ||||||||
| ChEMBL | Agonist activity at S1P4 receptor (unknown origin) | B | 4.3 | pEC50 | >50000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6346-6349 [PMID:24135724] |
| S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
| ChEMBL | Agonist activity at S1P5 receptor (unknown origin) | B | 4.6 | pEC50 | >25000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 6346-6349 [PMID:24135724] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
