A-971432 [Ligand Id: 9496] activity data from GtoPdb

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  • S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453]
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  • S1P5 receptor in Human [GtoPdb: 279] [UniProtKB: Q9H228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453]
GtoPdb - - 6.44 pIC50 362 nM IC50 J. Med. Chem. (2015) 58: 9154-70 [PMID:26509640]
S1P5 receptor in Human [GtoPdb: 279] [UniProtKB: Q9H228]
GtoPdb In a GTPγS assay using membranes from S1P5-transfected HEK293 cells. - 8.24 pEC50 5.7 nM EC50 J. Med. Chem. (2015) 58: 9154-70 [PMID:26509640];
Hum. Mol. Genet. (2018) 27: 2490-2501 [PMID:29688337]
GtoPdb In a forskolin-induced cAMP inhibition assay in S1P5-transfected CHO cells. - 8.39 pEC50 4.1 nM EC50 J. Med. Chem. (2015) 58: 9154-70 [PMID:26509640]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.