ChEMBL ligand: CHEMBL2005186 (Belumosudil, KD025, KD-025, Rock2 inhibitor kd025, SLx-2119, Slx-2119 free base)
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL	Inhibition of ROCK1 (unknown origin)	B	4.62	pKi	24000	nM	Ki	Bioorg Med Chem Lett (2020) 30: 127474-127474 [PMID:32805407]
ChEMBL	Inhibition of ROCK1 (unknown origin)	B	7.4	pKi	40	nM	Ki	J Med Chem (2018) 61: 9811-9840 [PMID:29969256]
GtoPdb	In a radiometric cell-free enzyme assay.	-	4.62	pIC50	24000	nM	IC50	Blood Coagul Fibrinolysis (2008) 19: 709-18 [PMID:18832915]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL	Inhibition of ROCK2 (unknown origin)	B	6.98	pKi	105	nM	Ki	Bioorg Med Chem Lett (2020) 30: 127474-127474 [PMID:32805407]
GtoPdb	In a radiometric cell-free enzyme assay.	-	6.98	pIC50	105	nM	IC50	Blood Coagul Fibrinolysis (2008) 19: 709-18 [PMID:18832915]
ChEMBL	Inhibition of ROCK2 (unknown origin)	B	7	pIC50	100	nM	IC50	J Med Chem (2018) 61: 9811-9840 [PMID:29969256]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]