KD025 [Ligand Id: 9558] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2005186 (KD-025, SLx-2119)
  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of ROCK1 (unknown origin) B 7.4 pKi 40 nM Ki J Med Chem (2018) 61: 9811-9840 [PMID:29969256]
GtoPdb In a radiometric cell-free enzyme assay. - 4.62 pIC50 24000 nM IC50 Blood Coagul. Fibrinolysis (2008) 19: 709-18 [PMID:18832915]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
GtoPdb In a radiometric cell-free enzyme assay. - 6.98 pIC50 105 nM IC50 Blood Coagul. Fibrinolysis (2008) 19: 709-18 [PMID:18832915]
ChEMBL Inhibition of ROCK2 (unknown origin) B 7 pIC50 100 nM IC50 J Med Chem (2018) 61: 9811-9840 [PMID:29969256]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]