clodronic acid [Ligand Id: 9605] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL12318 (Clodronic acid)
  • Type IV secretion-like conjugative transfer relaxase protein TraI in Escherichia coli (strain SMS-3-5 / SECEC) [ChEMBL: CHEMBL4296318] [UniProtKB: B1LRJ1]
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  • Vesicular nucleotide transporter in Human [GtoPdb: 1010] [UniProtKB: Q9BYT1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Type IV secretion-like conjugative transfer relaxase protein TraI in Escherichia coli (strain SMS-3-5 / SECEC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296318] [UniProtKB: B1LRJ1]
ChEMBL Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assay B 8.52 pKi 3 nM Ki Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 12282-12287 [PMID:17630285]
Vesicular nucleotide transporter in Human [GtoPdb: 1010] [UniProtKB: Q9BYT1]
GtoPdb Using a quantitative transport assay system involving proteoliposomes containing only expressed and purified protein. - 7.81 pIC50 15.6 nM IC50 Proc Natl Acad Sci USA (2017) 114: E6297-E6305 [PMID:28720702]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]