cevimeline [Ligand Id: 9658] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL168815 (Cevimeline) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Displacement of [3H]NMS from human muscarinic M1 receptor transfected in CHO cells after 120 mins by scintillation counting analysis | B | 5.31 | pKi | 4897.79 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 3255-3259 [PMID:24980056] |
| GtoPdb | Displacement of [3H]QNB from cloned receptor. | - | 5.31 | pKi | 4850 | nM | Ki | J Pharmacol Exp Ther (1997) 283: 1059-68 [PMID:9399977] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis | B | 6.07 | pKi | 851.14 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 3255-3259 [PMID:24980056] |
| GtoPdb | Displacement of [3H]QNB from cloned receptor. | - | 6.07 | pKi | 854 | nM | Ki | J Pharmacol Exp Ther (1997) 283: 1059-68 [PMID:9399977] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Displacement of [3H]NMS from human muscarinic M3 receptor transfected in CHO cells after 120 mins by scintillation counting analysis | B | 5.59 | pKi | 2570.4 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 3255-3259 [PMID:24980056] |
| GtoPdb | Displacement of [3H]QNB from cloned receptor. | - | 5.59 | pKi | 2575 | nM | Ki | J Pharmacol Exp Ther (1997) 283: 1059-68 [PMID:9399977] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | Displacement of [3H]QNB from cloned receptor. | - | 5.99 | pKi | 1012 | nM | Ki | J Pharmacol Exp Ther (1997) 283: 1059-68 [PMID:9399977] |
| ChEMBL | Displacement of [3H]NMS from human muscarinic M4 receptor transfected in CHO cells after 120 mins by scintillation counting analysis | B | 5.99 | pKi | 1023.29 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 3255-3259 [PMID:24980056] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
