ChEMBL ligand: CHEMBL3358954 (Bi 653048)
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] Glucocorticoid receptor in Mouse [ChEMBL: CHEMBL3144] [GtoPdb: 625] [UniProtKB: P06537] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Interleukin-6 in Human [ChEMBL: CHEMBL1795129] [UniProtKB: P05231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	Transrepression of GR in human whole blood assessed as inhibition of LPS-induced TNF-alpha release preincubated for 45 mins followed by LPS addition after 18 hrs by AlphaLISA method	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2018) 61: 1785-1799 [PMID:29424542]
ChEMBL	Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene expression incubated for 24 hrs by beta-galactosidase reporter gene assay	B	7.08	pIC50	84	nM	IC50	J Med Chem (2018) 61: 1785-1799 [PMID:29424542]
GtoPdb	-	-	7.15	pIC50	70	nM	IC50	ACS Med Chem Lett (2014) 5: 1318-23 [PMID:25516791]
ChEMBL	Displacement of RU-486 from GR (unknown origin) by fluorescence polarization assay	B	7.26	pIC50	55	nM	IC50	ACS Med Chem Lett (2014) 5: 1318-1323 [PMID:25516791]
ChEMBL	Fluorescence polarization assay	B	7.26	pIC50	55	nM	IC50	Data for DCP probe BI 653048
ChEMBL	Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production	B	7.64	pIC50	23	nM	IC50	ACS Med Chem Lett (2014) 5: 1318-1323 [PMID:25516791]
ChEMBL	Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assay	B	7.72	pIC50	19	nM	IC50	J Med Chem (2018) 61: 1785-1799 [PMID:29424542]
Glucocorticoid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3144] [GtoPdb: 625] [UniProtKB: P06537]
ChEMBL	Agonist activity at GR in mouse RAW cells assessed as suppression of TNF-alpha-induced IL-6 production	B	6.22	pIC50	600	nM	IC50	ACS Med Chem Lett (2014) 5: 1318-1323 [PMID:25516791]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG channel expressed in recombinant HEK293 cells by whole cell patch-clamp technique	B	4.52	pIC50	>30000	nM	IC50	ACS Med Chem Lett (2014) 5: 1318-1323 [PMID:25516791]
Interleukin-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795129] [UniProtKB: P05231]
ChEMBL	Fibroblast IL-6 assay	B	7.64	pIC50	23	nM	IC50	Data for DCP probe BI 653048

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]