(+)-SJ733 [Ligand Id: 9723] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4207489 (Sj-733, Sj733, SJ733) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring ATP4 S358S mutant | F | 5.07 | pIC50 | 8563 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antiplasmodial activity against PfATP4 inhibitor SJ557733-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by Griffith assay based fluorescence analysis | F | 5.1 | pIC50 | >8000 | nM | IC50 | Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708] |
| ChEMBL | Antimalarial activity against synchronous ring stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by Griffith assay based fluorescence analysis | F | 7.23 | pIC50 | 58.7 | nM | IC50 | Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708] |
| ChEMBL | Antimalarial activity against wild type Plasmodium falciparum Dd2 | F | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antimalarial activity against chloroquine sensitive/sulfadoxine resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth after 72 hrs by Sybr green dye based spectrophotometry | F | 7.44 | pEC50 | 36 | nM | EC50 | J Med Chem (2016) 59: 7950-7962 [PMID:27505686] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum V1/S [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.22 | pEC50 | 60 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.4 | pEC50 | 40 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pEC50 | 30 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum Dd2 [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.7 | pEC50 | 20 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
