(+)-SJ733 [Ligand Id: 9723] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4207489 (Sj733, SJ733, Sj-733, (+)-SJ733) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring ATP4 S358S mutant | F | 5.07 | pIC50 | 8563 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antiplasmodial activity against PfATP4 inhibitor SJ557733-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by Griffith assay based fluorescence analysis | F | 5.1 | pIC50 | >8000 | nM | IC50 | Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708] |
| ChEMBL | Antimalarial activity against synchronous ring stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by Griffith assay based fluorescence analysis | F | 7.23 | pIC50 | 58.7 | nM | IC50 | Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708] |
| ChEMBL | Antimalarial activity against wild type Plasmodium falciparum Dd2 | F | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2018) 61: 4213-4227 [PMID:29665687] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 harboring plasmodium falciparum ATP4 G358S mutant by SYBR green staining based analysis | F | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against W454-resistant population 1 Plasmodium falciparum 3D7 harboring Plasmodium falciparum ATP4 L928F mutant by LDH assay | F | 6.24 | pEC50 | 579 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against W454-resistant population 2 Plasmodium falciparum 3D7 harboring Plasmodium falciparum ATP4 L928F mutant by LDH assay | F | 6.27 | pEC50 | 537 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against W454-resistant population 3 Plasmodium falciparum 3D7 harboring Plasmodium falciparum ATP4 L928F mutant by LDH assay | F | 6.27 | pEC50 | 533 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against N-(2,6-difluorophenyl)-2-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide-resistant Plasmodium falciparum Dd2 harbouring ATP4 genome with 2.8 fold CNV by SYBR green staining based analysis | F | 6.87 | pEC50 | 136 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against N-(2,6-difluorophenyl)-2-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide-resistant Plasmodium falciparum Dd2 harboring plasmodium falciparum ATP4 F156L mutant by SYBR green staining based analysis | F | 6.95 | pEC50 | 112 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 harboring plasmodium falciparum ATP4 I398F/P990R/D1247Y mutant by SYBR green staining based analysis | F | 7.02 | pEC50 | 95 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against N-(2,6-difluorophenyl)-2-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indol-1-yl)acetamide-resistant Plasmodium falciparum Dd2 harboring plasmodium falciparum ATP4 D425E mutant by SYBR green staining based analysis | F | 7.1 | pEC50 | 79 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human HepG2 cells incubated for 72 hrs | F | 7.21 | pEC50 | 61 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against wild type Plasmodium falciparum 3D7 incubated for 48 hrs | F | 7.37 | pEC50 | 43 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| ChEMBL | Antiplasmodial activity against multidrug resistant asexual Plasmodium falciparum 3D7 infected in RBC incubated for 72 hrs by SYBR staining based fluorometer assay | F | 7.37 | pEC50 | 43 | nM | EC50 | J Med Chem (2024) 67: 14493-14523 [PMID:39134060] |
| ChEMBL | Antimalarial activity against chloroquine sensitive/sulfadoxine resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth after 72 hrs by Sybr green dye based spectrophotometry | F | 7.44 | pEC50 | 36 | nM | EC50 | J Med Chem (2016) 59: 7950-7962 [PMID:27505686] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum assessed as reduction in parasitic growth in erythrocytic stage | F | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020] |
| Plasmodium knowlesi (target type: ORGANISM) [ChEMBL: CHEMBL613011] | ||||||||
| ChEMBL | Antiplasmodial activity against multidrug resistant Plasmodium knowlesi YH1 infected in RBC incubated for 48 hrs by SYBR staining based fluorometer assay | F | 6.64 | pEC50 | 230 | nM | EC50 | J Med Chem (2024) 67: 14493-14523 [PMID:39134060] |
| ChEMBL | Antiplasmodial activity against wild type Plasmodium knowlesi YH1 incubated for 30 hrs by SYBR staining based flow cytometry assay | F | 6.64 | pEC50 | 227 | nM | EC50 | J Med Chem (2025) 68: 8933-8966 [PMID:40228810] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum V1/S [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.22 | pEC50 | 60 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.4 | pEC50 | 40 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pEC50 | 30 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
| Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum Dd2 [GtoPdb: 2971] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.7 | pEC50 | 20 | nM | EC50 | Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
