NGD 94-1 [Ligand Id: 979] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL103772 ([3H]NGD-941)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
There should be some charts here, you may need to enable JavaScript!
  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
There should be some charts here, you may need to enable JavaScript!
  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • D4 receptor in Rat [GtoPdb: 217] [UniProtKB: P30729]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity on human Dopamine receptor D2 expressed in CHO cells using radioligand [3H]-YM 09151 B 5.65 pKi 2250 nM Ki J. Med. Chem. (1997) 40: 1-3 [PMID:9016321]
ChEMBL Inhibition of human dopamine D2 receptor B 5.65 pKi 2230 nM Ki J Med Chem (2017) 60: 7233-7243 [PMID:28489950]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity on human Dopamine receptor D3 expressed in CHO cells using radioligand [3H]-YM 09151 B 5.1 pKi >8000 nM Ki J. Med. Chem. (1997) 40: 1-3 [PMID:9016321]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity on human Dopamine receptor D4 expressed in CHO cells using radioligand [3H]-YM 09151 B 8.42 pKi 3.8 nM Ki J. Med. Chem. (1997) 40: 1-3 [PMID:9016321]
ChEMBL Binding affinity towards human dopamine receptor D4 B 8.44 pKi 3.6 nM Ki J. Med. Chem. (2001) 44: 477-501 [PMID:11170639]
D4 receptor in Rat [GtoPdb: 217] [UniProtKB: P30729]
GtoPdb - - 9.5 pKi - - - Mol Pharmacol (2004) 66: 1491-9 [PMID:15448188]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A receptor B 6.74 pKi 181 nM Ki J. Med. Chem. (1997) 40: 1-3 [PMID:9016321]
ChEMBL Inhibition of serotonin 5-HT1A receptor (unknown origin) B 6.74 pKi 180 nM Ki J Med Chem (2017) 60: 7233-7243 [PMID:28489950]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Inhibition of serotonin 5-HT3 receptor (unknown origin) B 6.12 pKi 750 nM Ki J Med Chem (2017) 60: 7233-7243 [PMID:28489950]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]