butoxamine [Ligand Id: 9809] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL289093 (Butaxamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria | F | 4.35 | pKd | 44668.36 | nM | Kd | J Med Chem (1985) 28: 153-160 [PMID:2857200] |
| ChEMBL | Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atria | F | 4.35 | pKd | 44668.36 | nM | Kd | J Med Chem (1987) 30: 616-622 [PMID:2882026] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal strips | F | 6.89 | pKd | 128.82 | nM | Kd | J Med Chem (1985) 28: 153-160 [PMID:2857200] |
| ChEMBL | Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig trachea | F | 6.89 | pKd | 128.82 | nM | Kd | J Med Chem (1987) 30: 616-622 [PMID:2882026] |
| β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| β2-adrenoceptor in Rat [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
| GtoPdb | - | - | 6.51 | pKi | 309 | nM | Ki |
Jpn J Pharmacol (1990) 52: 195-200 [PMID:1968985]; Br J Pharmacol (1983) 79: 429-39 [PMID:6140042] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
