ChEMBL ligand: CHEMBL383824 (Alvespimycin, NSC-707545)
Heat shock protein 90 beta in Dog [ChEMBL: CHEMBL4748] [UniProtKB: P41148] There should be some charts here, you may need to enable JavaScript!
heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900] There should be some charts here, you may need to enable JavaScript!
heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238] There should be some charts here, you may need to enable JavaScript!
Hypoxia-inducible factor 1 alpha in Human [ChEMBL: CHEMBL4261] [UniProtKB: Q16665] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Heat shock protein 90 beta in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4748] [UniProtKB: P41148]
ChEMBL	Inhibition of BODIPY-AG binding to dog Grp94	B	7.19	pEC50	65	nM	EC50	J Med Chem (2006) 49: 4606-4615 [PMID:16854066]
heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900]
ChEMBL	Binding affinity for human heat shock protein 90 in scintillation proximity assay	B	6.3	pKd	500	nM	Kd	Bioorg Med Chem Lett (2005) 15: 5016-5021 [PMID:16165354]
ChEMBL	Binding affinity to human recombinant Hsp90alpha N-terminal domain by scintillation proximity assay	B	6.3	pKd	500	nM	Kd	J Med Chem (2009) 52: 1518-1521 [PMID:19231864]
ChEMBL	Binding affinity to human recombinant Hsp90alpha N-terminal domain by isothermal titration calorimetry	B	7.06	pKd	87	nM	Kd	J Med Chem (2009) 52: 1518-1521 [PMID:19231864]
ChEMBL	Displacement of [3H]-(R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide from human his(6)-tagged HSP90alpha after 30 mins by scintillation proximity assay	B	6.17	pKi	680	nM	Ki	J Med Chem (2011) 54: 3368-3385 [PMID:21438541]
ChEMBL	Inhibition of 6x-His tagged human recombinant full length Hsp90alpha ATPase preincubated for 0.5 hrs followed by ATP addition measured after 30 mins by HTRF assay	B	6.04	pIC50	919	nM	IC50	Bioorg Med Chem (2016) 24: 4626-4635 [PMID:27527413]
GtoPdb	-	-	8.35	pIC50	4.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6273-8 [PMID:18929486]
heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
ChEMBL	Binding affinity to human recombinant HSP90	B	6.3	pKd	500	nM	Kd	J Med Chem (2009) 52: 3265-3273 [PMID:19405528]
ChEMBL	Inhibition of full-length HSP90 (unknown origin) expressed in Escherichia coli assessed as inhibition of ATPase activity after 3 hrs by spectrophotometric analysis	B	5.85	pIC50	1410	nM	IC50	Eur J Med Chem (2014) 79: 399-412 [PMID:24763261]
ChEMBL	Inhibition of full-length Hsp90-ATPase activity (unknown origin) assessed as inhibition of ATP hydrolysis by spectrophotometry	B	6.03	pIC50	930	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1557-1561 [PMID:24582477]
ChEMBL	Displacement of FITC-geldanamycin from HSP90 (unknown origin) after 30 mins by fluorescence polarization assay	B	7.05	pIC50	90	nM	IC50	Eur J Med Chem (2014) 79: 399-412 [PMID:24763261]
ChEMBL	Binding affinity to Hsp90 in human SKBR3 cells	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem (2009) 17: 2225-2235 [PMID:19017562]
Hypoxia-inducible factor 1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4261] [UniProtKB: Q16665]
ChEMBL	Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis	F	7.24	pIC50	57.2	nM	IC50	J Nat Prod (2009) 72: 39-43 [PMID:19072214]
ChEMBL	Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis	F	7.24	pIC50	57	nM	IC50	J Nat Prod (2010) 73: 1167-1169 [PMID:20469887]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]