ozagrel [Ligand Id: 9866] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL11662 (Ozagrel sodium, Ozagrel, KCT-0809)
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1994) 37: 3588-3604 [PMID:7932586]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL Inhibitory activity against Thromboxane A2 synthase in human platelet microsome B 5 pIC50 10000 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 1087-1090
ChEMBL Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomes F 5.85 pIC50 1400 nM IC50 J. Med. Chem. (1989) 32: 890-897 [PMID:2704033]
ChEMBL Tested in vitro against TXA2 synthetase inhibitory activity in human whole blood B 6.05 pIC50 900 nM IC50 J. Med. Chem. (1993) 36: 4061-4068 [PMID:8258828]
ChEMBL Tested in vitro against TXA2 synthetase inhibitory activity in human platelet B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1993) 36: 4061-4068 [PMID:8258828]
ChEMBL Tested in vitro against TXA2 synthetase inhibitory activity in human microsome B 7.22 pIC50 60 nM IC50 J. Med. Chem. (1993) 36: 4061-4068 [PMID:8258828]
ChEMBL In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. F 7.62 pIC50 24 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 341-344 [PMID:11814792]
ChEMBL In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)] F 7.62 pIC50 24 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 771-774 [PMID:11858999]
ChEMBL Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes B 7.62 pIC50 24 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 1383-1386 [PMID:11992782]
GtoPdb Inhibition of TXAB2 synthesis by microsome of human platelets. - 8.22 pIC50 6 nM IC50 J Med Chem (1996) 39: 3148-57 [PMID:8759636]
GtoPdb Inhibition of thromboxane A2 synthetase activity in human washed platelets. - 8.4 pIC50 4 nM IC50 Jpn J Pharmacol (1986) 41: 393-401 [PMID:3093741]
CYP5A1/Thromboxane-A synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430]
ChEMBL In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees Centigrade B 6.19 pIC50 640 nM IC50 J. Med. Chem. (1994) 37: 3588-3604 [PMID:7932586]
ChEMBL Tested in vitro against TXA2 synthetase inhibitory activity in rat platelet B 6.7 pIC50 200 nM IC50 J. Med. Chem. (1993) 36: 4061-4068 [PMID:8258828]
ChEMBL Tested in vitro against TXA2 synthetase inhibitory activity in rat whole blood B 6.7 pIC50 200 nM IC50 J. Med. Chem. (1993) 36: 4061-4068 [PMID:8258828]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]