pexmetinib [Ligand Id: 9917] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| mitogen-activated protein kinase 11 in Human [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| GtoPdb | - | - | 7.59 | pIC50 | 26 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| GtoPdb | - | - | 7.55 | pIC50 | 28 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| GtoPdb | - | - | 7.33 | pIC50 | 47 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| GtoPdb | - | - | 7.38 | pIC50 | 42 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| TEK receptor tyrosine kinase in Human [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| ABL proto-oncogene 2, non-receptor tyrosine kinase in Human [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| GtoPdb | - | - | 7.39 | pIC50 | 41 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| HCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
| GtoPdb | - | - | 7.59 | pIC50 | 26 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
| misshapen like kinase 1 in Human [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
| GtoPdb | - | - | 7.59 | pIC50 | 26 | nM | IC50 | Cancer Res (2016) 76: 4841-4849 [PMID:27287719] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
