atabecestat [Ligand Id: 9963] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| beta-secretase 1 in Human [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| GtoPdb | BInding affinity determined in a competitive radioligand binding assay using the nonselective BACE1/2 inhibitor [3H] JNJ-962 | - | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2021) 64: 14165-14174 [PMID:34553947] |
| GtoPdb | - | - | 8.01 | pIC50 | 9.8 | nM | IC50 | Discovery and synthesis of JNJ-54861911, a novel orally active BACE1 inhibitor. CiteUlike |
| beta-secretase 2 in Human [GtoPdb: 2331] [UniProtKB: Q9Y5Z0] | ||||||||
| GtoPdb | BInding affinity determined in a competitive radioligand binding assay using the nonselective BACE1/2 inhibitor [3H] JNJ-962 | - | 8.02 | pKi | 9.6 | nM | Ki | J Med Chem (2021) 64: 14165-14174 [PMID:34553947] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
