AUNP-12

Ligand id: 10117

Name: AUNP-12

Structure and Physico-chemical Properties

2D Structure
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Classification
Compound class Peptide or derivative
Synonyms
Aur-012 | Aurigene NP-12 | Aurigene-012 | compound #8 [WO2011161699A3]
Comments
AUNP-12 is a small branched peptide inhibitor of the PD-1/PD-L1 pathway that was developed by Aurigene Discovery Technologies and is claimed in their patent WO2011161699A3 [1]. It interacts with PD-1 and prevents binding of both PD-L1 and PD-L2 [3]. It is composed of two linked peptide chains (sequence 1 SNTSESFKFRVTQLAPKAQIKE and sequence 2 SNTSESF), with a total of 29 amino acids. Peptidic antagonists of PD-1 binding by PD-L1/L2 such as AUNP-12 are being developed with the aim of overcoming the pharmacokinetic, manufacture and useage limitations of the current monoclonal antibody PD-1 pathway inhibitors, as well as reducing some of their severe immune-related adverse events [2].
Database Links
CAS Registry No. 131709240 (source: PubChem)
GtoPdb PubChem SID 381118827
PubChem CID 131709240
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