Synonyms: TH-5487
Compound class:
Synthetic organic
Comment: TH5487 is a selective, active-site inhibitor of 8-oxoguanine DNA glycosylase (OGG1) [2]. OGG1 repairs 8-hydroxy-2′-deoxyguanosine (8-oxoG) DNA defects that can be induced by reactive oxygen species (ROS) at sites of inflammation. TH5487 inhibits OGG1-mediated proinflammatory activity in allergic states. In a mouse model of allergic airway inflammation TH5487 reduced NF-κB-mediated expression of proinflammatory cytokines/chemokines and inhibited immune cell recruitment into the lungs with an associated reduction in goblet cell hyperplasia and mucus production [1].
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Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
TH-5487 |
Database Links ![]() |
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GtoPdb PubChem SID | 381118894 |
PubChem CID | 137321164 |
RCSB PDB Ligand | K8Q |
Search Google for chemical match using the InChIKey | FZLKVWWPFOLPKF-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | FZLKVWWPFOLPKF |
UniChem Compound Search for chemical match using the InChIKey | FZLKVWWPFOLPKF-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FZLKVWWPFOLPKF-UHFFFAOYSA-N |