FzM1.8   Click here for help

GtoPdb Ligand ID: 10321

Compound class: Synthetic organic
Comment: FzM1.8 is a small-molecule allosteric agonist of FZD4 and activates the WNT/β-catenin pathway [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 98.66
Molecular weight 322.1
XLogP 2.96
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(Nc1ccc2c(c1)cccc2)Nc1cc(O)cc(c1)C(=O)O
Isomeric SMILES O=C(Nc1ccc2c(c1)cccc2)Nc1cc(O)cc(c1)C(=O)O
InChI InChI=1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24)
InChI Key XGNNCRZDDAJBFU-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
3-hydroxy-5-{[(naphthalen-2-yl)carbamoyl]amino}benzoic acid
Database Links Click here for help
GtoPdb PubChem SID 381745002
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Tocris
FzM1.8
Cat. No. 6961