BL-1249   Click here for help

GtoPdb Ligand ID: 10336

Synonyms: BL1249
Compound class: Synthetic organic
Comment: BL-1249 is a K2P channel activator [1]. It activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) ∼10-fold more potently than K2P4.1 (TRAAK).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 66.49
Molecular weight 291.15
XLogP 4.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C1CCc2c(C1)c(ccc2)Nc1ccccc1c1n[nH]nn1
Isomeric SMILES C1CCc2c(C1)c(ccc2)Nc1ccccc1c1n[nH]nn1
InChI InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
InChI Key YYNRZIFBTOUICE-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-[2-(2H-tetrazol-5-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-1-amine
Synonyms Click here for help
BL1249
Database Links Click here for help
BindingDB Ligand 50197060
CAS Registry No. 18200-13-0 (source: PubChem)
ChEMBL Ligand CHEMBL1417584
GtoPdb PubChem SID 381745017
PubChem CID 16078951
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Tocris
BL 1249
Cat. No. 3797