Synonyms: BAY-1895344 | BAY1895344
Compound class:
Synthetic organic
Comment: Elimusertib (BAY1895344) is a potent, highly selective and orally available ATR inhibitor. It was designed using a combination of medicinal chemistry, pharmacology, DMPK (drug metabolism and pharmacokinetics) and computational chemistry. ATR responds to a broad spectrum of DNA damage and activates the DNA damage response (DDR) pathway. By preventing DNA repair in cancer cells (which are under replication stress and suffer from increased DNA damage and defective DNA damage repair), inhibition of ATR is expected to drive the cancer cells towards cell cycle arrest and cell death [2-3].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(3R)-3-methyl-4-[4-(2-methylpyrazol-3-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine |
International Nonproprietary Names ![]() |
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INN number | INN |
11490 | elimusertib |
Synonyms ![]() |
BAY-1895344 | BAY1895344 |
Database Links ![]() |
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CAS Registry No. | 1876467-74-1 (source: PubChem) |
GtoPdb PubChem SID | 384403635 |
PubChem CID | 118869362 |
Search Google for chemical match using the InChIKey | YBXRSCXGRPSTMW-CYBMUJFWSA-N |
Search Google for chemicals with the same backbone | YBXRSCXGRPSTMW |
Search PubMed clinical trials | elimusertib |
Search PubMed titles | elimusertib |
Search PubMed titles/abstracts | elimusertib |
UniChem Compound Search for chemical match using the InChIKey | YBXRSCXGRPSTMW-CYBMUJFWSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YBXRSCXGRPSTMW-CYBMUJFWSA-N |