AM237   Click here for help

GtoPdb Ligand ID: 10421

Synonyms: Example 319 [WO2014143799]
Compound class: Synthetic organic
Comment: AM237 is a potent and selective TRPC5 channel activator [2]. It is an analogue of the TRPC1/4/5 channel inhibitor Pico145. Whilst AM237 activates homomeric TRPC5 channels it inhibits other TRPC1/4/5 channels, and is proposed as a useful chemical tool to help investigate TRPC1/4/5 channel composition and the biological functions of specific channels in different cells and/or tissues. It is orally bioavailable and suitable for in vivo studies. AM237 is one of the xanthine derivatives claimed in patent WO2014143799A2 [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 100.51
Molecular weight 558.07
XLogP 7.23
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCCCn1c(=O)c2n(Cc3ccc(cc3)Cl)c(nc2n(c1=O)C)Oc1ccc(c(c1)OC(F)(F)F)Cl
Isomeric SMILES OCCCn1c(=O)c2n(Cc3ccc(cc3)Cl)c(nc2n(c1=O)C)Oc1ccc(c(c1)OC(F)(F)F)Cl
InChI InChI=1S/C23H19Cl2F3N4O5/c1-30-19-18(20(34)31(22(30)35)9-2-10-33)32(12-13-3-5-14(24)6-4-13)21(29-19)36-15-7-8-16(25)17(11-15)37-23(26,27)28/h3-8,11,33H,2,9-10,12H2,1H3
InChI Key UNQYAAAWKOOBFQ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
7-[(4-chlorophenyl)methyl]-8-[4-chloro-3-(trifluoromethoxy)phenoxy]-1-(3-hydroxypropyl)-3-methylpurine-2,6-dione
Synonyms Click here for help
Example 319 [WO2014143799]
Database Links Click here for help
GtoPdb PubChem SID 385612181
PubChem CID 90403462
Search Google for chemical match using the InChIKey UNQYAAAWKOOBFQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone UNQYAAAWKOOBFQ
UniChem Compound Search for chemical match using the InChIKey UNQYAAAWKOOBFQ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey UNQYAAAWKOOBFQ-UHFFFAOYSA-N