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Synonyms: compound 57 [PMID: 30199637]
Compound class: Synthetic organic
Comment: LIT-001 is a non-peptide oxytocin (OT) receptor agonist . The compound is brain penetrant and active in vivo by intraperitoneal injection. OT receptor agonists are predicted to promote prosocial effects in individuals with disorders such as autism spectrum disorders (ASD), who exhibit social interaction deficits. LIT-001 provides an in vivo pharmacological tool compound that is suitable for furthering the study of the effects of OT receptor agonism in autism.
A search of PubChem for 'LIT-001' produces a single CID (137701510), but this is for the R optical isomer of the chemical structure. The primary reference for LIT-001 by Frantz et al. defines the molecule as the S isomer (and as the trifluoroacetate salt) .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|compound 57 [PMID: 30199637]|
|GtoPdb PubChem SID||385612204|
|Search Google for chemical match using the InChIKey||AOPORIRPXVMWSL-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||AOPORIRPXVMWSL|
|Search UniChem for chemical match using the InChIKey||AOPORIRPXVMWSL-UHFFFAOYSA-N|
|Search UniChem for chemicals with the same backbone||AOPORIRPXVMWSL|