bilorphin

Ligand id: 10518

Name: bilorphin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 16
Topological polar surface area 176.64
Molecular weight 553.33
XLogP 2.38
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
peptide 3c [PMID: 31611414]
Comments
Bilorphin is a derivative of a naturally ocurring tetrapeptide that was isolated from an Australian estuarine isolate of Penicillium species MST-MF667 [1]. It acts as a G protein signalling biased agonist of the μ-opioid receptor in vitro. Bilorphin promotes minimal β-arrestin recruitment and receptor internalization. Systemic and oral activity was achieved by glycosylating the C-terminal residue of bilorphin to create bilactorphin. The in vivo analgesic potency of bilactorphin is similar to that of morphine.
Database Links
GtoPdb PubChem SID 387065600
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