delta like canonical Notch ligand 3   Click here for help

GtoPdb Ligand ID: 10560

Abbreviated name: DLL3
Synonyms: SCDO1
Comment: DLL3 is is an inhibitory NOTCH pathway ligand. The mature protein is 592 amino acids long and contains DSL and transmembrane domains, and EGF repeats that are characteristic of NOTCH family ligands. DLL3 can be detected in the cytoplasm of a few normal adult cell types (neurons, pancreatic islet cells, pituitary cells). In contrast, its expression is highly upregulated to the surface of malignant cells of neuroendocrine origin, including small cell lung cancer (SCLC) [4-5], melanoma, glioblastoma multiforme, small cell bladder cancer, metastatic castration-resistant prostate cancer, and neuroendocrine lung tumours, and is detected on cancer stem cells. Its favourable expression profile has enabled DLL3-targeted therapeutic development for these cancer indications [2-3]. To date, DLL3-targeted therapies include an antibody-drug conjugate (rovalpituzumab tesirine; max phase 3, development terminated), a bispecific T cell engager (tarlatamab, formerly AMG757; max phase 3) and a chimeric antigen receptor T cell therapy (AMG119; max phase 1), all of which were first evaluated in advanced SCLC.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
DLL3 delta like canonical Notch ligand 3 Human delta-like protein 3 isoform 1 precursor -
Database Links Click here for help
Ensembl Gene ENSG00000090932 (Hs)
Entrez Gene 10683 (Hs)
GtoPdb PubChem SID 404859007
Human Protein Atlas ENSG00000090932 (Hs)
OMIM 602768 (Hs)
RefSeq Nucleotide NM_016941 (Hs)
RefSeq Protein NP_058637 (Hs)
UniProtKB Q9NYJ7 (Hs)