licogliflozin   Click here for help

GtoPdb Ligand ID: 10654

Synonyms: example 62 [WO2011048112A1] | LIK-066 | LIK066
Compound class: Synthetic organic
Comment: Licogliflozin (LIK-066) is an orally bioactive inhibitor of sodium/glucose cotransporters 1 and 2 (SGLT1, SGLT2). It was developed by Novartis for the treatment of obesity, non-alcoholic steatohepatitis, and type 2 diabetes, but the program was discontinued in 2018 [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 108.61
Molecular weight 416.18
XLogP 2.44
No. Lipinski's rules broken 0
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Canonical SMILES OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc3c(c2)OCCO3)CC)[C@@H]([C@H]([C@@H]1O)O)O
Isomeric SMILES OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc3c(c2)OCCO3)CC)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C23H28O7/c1-2-14-4-5-15(23-22(27)21(26)20(25)19(12-24)30-23)11-16(14)9-13-3-6-17-18(10-13)29-8-7-28-17/h3-6,10-11,19-27H,2,7-9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10703 licogliflozin
Synonyms Click here for help
example 62 [WO2011048112A1] | LIK-066 | LIK066
Database Links Click here for help
CAS Registry No. 1291094-73-9 (source: WHO INN record)
GtoPdb PubChem SID 404859101
PubChem CID 52913524
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