JNJ-42226314

Ligand id: 10661

Name: JNJ-42226314

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 89.4
Molecular weight 489.16
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[1-(4-fluorophenyl)indol-5-yl]-[3-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone
Synonyms
JNJ 42226314 | JNJ42226314
Comments
A potent, selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor that demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol as well as efficacy in models of neuropathic and inflammatory pain.
Database Links
GtoPdb PubChem SID 404859108
PubChem CID 59625954
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