HWL-088   Click here for help

GtoPdb Ligand ID: 10668

Synonyms: CS-0105155 | HWL 088 | HWL088 | HY-130120
Compound class: Synthetic organic
Comment: HWL-088 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist bearing a phenoxyacetic acid scaffold. HWL-088 significantly improves glucose tolerance in normal and diabetic models.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.76
Molecular weight 366.13
XLogP 5.48
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C
Isomeric SMILES OC(=O)COc1ccc(cc1F)OCc1cccc(c1)c1ccccc1C
InChI InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
InChI Key NJYJBYPNDWNZAH-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[2-fluoro-4-[[3-(2-methylphenyl)phenyl]methoxy]phenoxy]acetic acid
Synonyms Click here for help
CS-0105155 | HWL 088 | HWL088 | HY-130120
Database Links Click here for help
CAS Registry No. 2378617-96-8
GtoPdb PubChem SID 404859115
PubChem CID 139600331
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