Synonyms: MMPD | VX-497 | VX497
Compound class:
Synthetic organic
Comment: Merimepodib is an orally bioavailable, non-competitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) [4]. It has antiviral activity, suppressing replication of Zika virus (ZIKV) [2], hepatitis C virus (HCV), and other emerging viral pathogens [5]. IMPDH inhibition reduces intracellular guanine nucleotide levels, thus limiting RNA and DNA synthesis both for cellular proliferation, and for viral replication inside host cells. Experimental evidence shows that the activity of merimepodib can augment the anti-replicative effects of other antivirals such as ribavirin and T-705 (favipiravir).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
International Nonproprietary Names ![]() |
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INN number | INN |
8123 | merimepodib |
Synonyms ![]() |
MMPD | VX-497 | VX497 |
Database Links ![]() |
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CAS Registry No. | 198821-22-6 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL304087 |
GtoPdb PubChem SID | 405067333 |
PubChem CID | 153241 |
Search Google for chemical match using the InChIKey | JBPUGFODGPKTDW-SFHVURJKSA-N |
Search Google for chemicals with the same backbone | JBPUGFODGPKTDW |
Search PubMed clinical trials | merimepodib |
Search PubMed titles | merimepodib |
Search PubMed titles/abstracts | merimepodib |
UniChem Compound Search for chemical match using the InChIKey | JBPUGFODGPKTDW-SFHVURJKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JBPUGFODGPKTDW-SFHVURJKSA-N |
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Merimepodib (links to external site)
Cat. No. HY-13986 |