contezolid   Click here for help

GtoPdb Ligand ID: 10795

Synonyms: MRX-1 | MRX-I | Youxitai®
Approved drug PDB Ligand
contezolid is an approved drug (China (2021))
Compound class: Synthetic organic
Comment: Contezolid is an oxazolidinone antibacterial against Gram-positive pathogens [1], including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae, penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). Its orally delivered prodrug is contezolid acefosamil (parent) (MRX-4). Contezolid targets protein synthesis by binding to the V region of the bacterial 23S rRNA.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 87.91
Molecular weight 408.1
XLogP 2.44
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C1CCN(C=C1)c1c(F)cc(c(c1F)F)N1C[C@@H](OC1=O)CNc1ccon1
Isomeric SMILES O=C1CCN(C=C1)c1c(F)cc(c(c1F)F)N1C[C@@H](OC1=O)CNc1ccon1
InChI InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1
InChI Key SULYVXZZUMRQAX-NSHDSACASA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (China (2021))
Prodrug contezolid acefosamil (parent)
IUPAC Name Click here for help
(5S)-5-[(1,2-oxazol-3-ylamino)methyl]-3-[2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridin-1-yl)phenyl]-1,3-oxazolidin-2-one
International Nonproprietary Names Click here for help
INN number INN
10775 contezolid
Synonyms Click here for help
MRX-1 | MRX-I | Youxitai®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Contezolid (MRX-4/MRX-1)
Other databases
BindingDB Ligand 50017203
CAS Registry No. 1112968-42-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL3287379
GtoPdb PubChem SID 405560236
PubChem CID 25184541
RCSB PDB Ligand ZC0
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UniChem Compound Search for chemical match using the InChIKey SULYVXZZUMRQAX-NSHDSACASA-N
UniChem Connectivity Search for chemical match using the InChIKey SULYVXZZUMRQAX-NSHDSACASA-N