oxytetracycline

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Ligands
oxytetracycline

GtoPdb Ligand ID: 10919

Synonyms: E703 | NSC-9169 | Terramycin®

oxytetracycline is an approved drug (FDA (1964), UK (2011))

Compound class: Natural product

Comment: Oxytetracycline is a tetracycline class antibacterial originally isolated from the soil-dwelling actinomycete Streptomyces rimosus [1]. It has activity against Gram-positive and Gram-negative bacteria, including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae.

oxytetracycline is commercially available from our sponsors

2D Structure

Physico-chemical Properties

Hydrogen bond acceptors	10
Hydrogen bond donors	7
Rotatable bonds	2
Topological polar surface area	201.85
Molecular weight	460.15
XLogP	-0.77
No. Lipinski's rules broken	1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

SMILES / InChI / InChIKey

Canonical SMILES	CN([C@@H]1C(=O)C(=C([C@@]2([C@H]1[C@@H](O)[C@H]1C(=C(O)c3c([C@@]1(C)O)cccc3O)C2=O)O)O)C(=O)N)C
Isomeric SMILES	CN([C@@H]1C(=O)C(=C([C@@]2([C@H]1[C@@H](O)[C@H]1C(=C(O)c3c([C@@]1(C)O)cccc3O)C2=O)O)O)C(=O)N)C
InChI	InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
InChI Key	OWFJMIVZYSDULZ-PXOLEDIWSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)