Synonyms: Gantanol® | RO 4-2130 | RO-42130 | SMX | STX-608
sulfamethoxazole is an approved drug (FDA (1965))
Compound class:
Synthetic organic
Comment: Sulfamethoxazole is a sulfonamide antibacterial that has bacteriostatic activity. It inhibits the bacterial dihydropteroate synthase pathway which generates the folic acid that is essential for bacterial growth. It is active against Gram-negative and Gram-positive bacteria including Listeria monocytogenes and E. coli.
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1965)) |
Approved drug? | Yes. FDA (1965) |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name ![]() |
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
International Nonproprietary Names ![]() |
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INN number | INN |
1386 | sulfamethoxazole |
Synonyms ![]() |
Gantanol® | RO 4-2130 | RO-42130 | SMX | STX-608 |
Database Links ![]() |
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Specialist databases | |
Antibiotic DB
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Sulfamethoxazole |
Other databases | |
CAS Registry No. | 723-46-6 (source: PubChem) |
ChEMBL Ligand | CHEMBL443 |
DrugBank Ligand | DB01015 |
DrugCentral Ligand | 2514 |
GtoPdb PubChem SID | 405560374 |
PubChem CID | 5329 |
RCSB PDB Ligand | 08D |
Search Google for chemical match using the InChIKey | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | JLKIGFTWXXRPMT |
Search PubMed clinical trials | sulfamethoxazole |
Search PubMed titles | sulfamethoxazole |
Search PubMed titles/abstracts | sulfamethoxazole |
UniChem Compound Search for chemical match using the InChIKey | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
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Sulfamethoxazole (links to external site)
Cat. No. HY-B0322
Sulfamethoxazole (Standard) (links to external site)
Cat. No. HY-B0322R |