Corallopyronin A   Click here for help

GtoPdb Ligand ID: 11029

Synonyms: CorA | LS-54950 | LS54950
Compound class: Natural product
Comment: Corallopyronin A is a polyketide-peptide antibacterial produced by myxobacterium Corallococcus coralloides B035 [1-2,5]. It has potent anti-filarial activity [3-4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 16
Topological polar surface area 126.07
Molecular weight 527.29
XLogP 5.42
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C/C=C/C/C=C(/C(CC/C(=C/C=C(/C(=O)c1c(O)cc(oc1=O)C(CC/C=C/NC(=O)OC)C)\C)/C)O)\C
Isomeric SMILES C/C=C/C/C=C(/C(CC/C(=C/C=C(/C(=O)c1c(O)cc(oc1=O)C(CC/C=C/NC(=O)OC)C)\C)/C)O)\C
InChI InChI=1S/C30H41NO7/c1-7-8-9-12-21(3)24(32)17-15-20(2)14-16-23(5)28(34)27-25(33)19-26(38-29(27)35)22(4)13-10-11-18-31-30(36)37-6/h7-8,11-12,14,16,18-19,22,24,32-33H,9-10,13,15,17H2,1-6H3,(H,31,36)/b8-7+,18-11+,20-14+,21-12+,23-16+
InChI Key FPBHSTHTCPCNBS-QXMYDWGFSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Bouhired S, Rupp O, Blom J, Schäberle TF, Schiefer A, Kehraus S, Pfarr K, Goesmann A, Hoerauf A, König G. (2019)
Complete Genome Sequence of the Corallopyronin A-Producing Myxobacterium Corallococcus coralloides B035.
Microbiol Resour Announc, 8 (17). [PMID:31023790]
2. Charousová I, Steinmetz H, Medo J, Javoreková S, Wink J. (2017)
Soil myxobacteria as a potential source of polyketide-peptide substances.
Folia Microbiol (Praha), 62 (4): 305-315. [PMID:28161814]
3. Pogorevc D, Panter F, Schillinger C, Jansen R, Wenzel SC, Müller R. (2019)
Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic.
Metab Eng, 55: 201-211. [PMID:31340171]
4. Schiefer A, Schmitz A, Schäberle TF, Specht S, Lämmer C, Johnston KL, Vassylyev DG, König GM, Hoerauf A, Pfarr K. (2012)
Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.
J Infect Dis, 206 (2): 249-57. [PMID:22586066]
5. Schmitz A, Kehraus S, Schäberle TF, Neu E, Almeida C, Roth M, König GM. (2014)
Corallorazines from the myxobacterium Corallococcus coralloides.
J Nat Prod, 77 (1): 159-63. [PMID:24422674]
6. Schäberle TF, Schmitz A, Zocher G, Schiefer A, Kehraus S, Neu E, Roth M, Vassylyev DG, Stehle T, Bierbaum G et al.. (2015)
Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives.
J Nat Prod, 78 (10): 2505-9. [PMID:26431157]