SENS-111   Click here for help

GtoPdb Ligand ID: 11072

Compound class: Synthetic organic
Comment: SENS-111 (Seliforant) is an orally available small molecule histamine type 4 receptor antagonist, displaying an inhibitory effect on vestibular neuron activity.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 67.07
Molecular weight 235.18
XLogP 1.78
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CNC1CN(C1)c1cc(N)nc(n1)CC(C)C
Isomeric SMILES CNC1CN(C1)c1cc(N)nc(n1)CC(C)C
InChI InChI=1S/C12H21N5/c1-8(2)4-11-15-10(13)5-12(16-11)17-6-9(7-17)14-3/h5,8-9,14H,4,6-7H2,1-3H3,(H2,13,15,16)
InChI Key QRBVUFXEMHNIDB-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
6-[3-(methylamino)azetidin-1-yl]-2-(2-methylpropyl)pyrimidin-4-amine
International Nonproprietary Names Click here for help
INN number INN
10575 seliforant
Database Links Click here for help
Specialist databases
GPCRdb Ligand SENS-111
Other databases
CAS Registry No. 1164115-89-2
GtoPdb PubChem SID 434122133
PubChem CID 44126305
Search Google for chemical match using the InChIKey QRBVUFXEMHNIDB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QRBVUFXEMHNIDB
Search PubMed clinical trials seliforant
Search PubMed titles seliforant
Search PubMed titles/abstracts seliforant
UniChem Compound Search for chemical match using the InChIKey QRBVUFXEMHNIDB-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey QRBVUFXEMHNIDB-UHFFFAOYSA-N