Synonyms: GX-15-070 | GX15-070 | obatoclax mesylate | SB16622
Compound class:
Synthetic organic
Comment: Obatoclax is a small molecule inhibitor of Bcl-2 family proteins. Bcl-2 inhibition induces apoptosis in cancer cells [3-4,7]. We have matched the chemical structure to PubChem using the CAS number assigned in the WHO INN record for this drug, but note that various cis/trans isomers have been submitted to PubChem, and also thta the INN record does not in fact stipulate bond rotations. Enclosure of obatoclax in red blood-cell membrane-derived nanoparticles has been tested to overcome the compound's poor solubility [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
International Nonproprietary Names | |
INN number | INN |
8691 | obatoclax |
Synonyms |
GX-15-070 | GX15-070 | obatoclax mesylate | SB16622 |
Database Links | |
CAS Registry No. | 803712-67-6 (source: WHO INN record) |
GtoPdb PubChem SID | 434122147 |
PubChem CID | 46930997 |
Search Google for chemical match using the InChIKey | CVCLJVVBHYOXDC-LKIBBAOUSA-N |
Search Google for chemicals with the same backbone | CVCLJVVBHYOXDC |
Search PubMed clinical trials | obatoclax |
Search PubMed titles | obatoclax |
Search PubMed titles/abstracts | obatoclax |
UniChem Compound Search for chemical match using the InChIKey | CVCLJVVBHYOXDC-LKIBBAOUSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CVCLJVVBHYOXDC-LKIBBAOUSA-N |